rs10987149 - PBX3 - MVB12B

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system - Unknown journal (n.d.) · Unknown authors · PubMed 24009623

  ABSTRACT: The mammalian target of rapamycin (mTOR) inhibitors, a set of promising potential anti-cancer agents, has shown response variability among individuals. This study aimed to identify novel biomarkers and mechanisms that might influence the response to Rapamycin and Everolimus. Genome-wide association (GWA) analyses involving single nucleotide polymorphisms (SNPs), mRNA, and microRNAs microarray data were assessed for association with area under the cytotoxicity dose response curve (AUC) of two mTOR inhibitors in 272 human lymphoblastoid cell lines (LCLs). Integrated analysis among SNPs, expression data, microRNA data and AUC values were also performed to help select candidate genes for further functional characterization. Functional validation of candidate genes using siRNA screeni

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