rs1098708 - C12orf71 - STK38L
Magnitude 2.2 · 2 studies on file
Reported associations
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Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits - Unknown journal (n.d.) · Unknown authors · PubMed 30224653
ABSTRACT: High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future. FULL TEXT: [INTRO] Introduction [INTRO] High blood pressure (BP) is a leading heritable risk factor for stroke and coronary artery disease, responsible for an es
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Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits - Unknown journal (n.d.) · Unknown authors · PubMed 39537608
ABSTRACT: Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared genetic architecture using multi-trait genome-wide association studies. Subsequent fine-mapping and colocalisation highlighted 16 genetic loci associated with both Alzheimer's and cardiovascular diseases. We prioritised rs11786896, which colocalised with Alzheimer's disease, atrial fibrillation and expression of PLEC in the heart left ventricle, and rs7529220, which colocalised with Alzheimer's disease, atrial fibrillation and expression of C1Q family genes. Single-cell RNA-sequencing data, co-expression network and protein-protein interaction analyses provided evidence for different mechanisms of PLEC, which is upregulated in left ventricular endothelium and cardiomyocyte
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic blood pressure predisposition Moderate
This SNP is associated with modest increases in diastolic and systolic blood pressure, suggesting cardiovascular risk assessment may be warranted.
Screening
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blood pressure Moderate
Genetic variants at this locus show strong associations with both diastolic and systolic blood pressure in large-scale GWAS studies.
Check blood pressure at least annually, more frequently if hypertension is detected