Expressive

rs10987077 - PBX3 - MVB12B

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduce GERD trigger foods Moderate

    rs10987077 is associated with GERD risk; dietary modifications reduce reflux symptom frequency

    limit or avoid spicy foods, fatty foods, chocolate, caffeine, and alcohol

Lifestyle

  • elevate head of bed for GERD prevention Moderate

    rs10987077 is associated with GERD risk; head elevation reduces nocturnal reflux events

    elevate head of bed 30-45 degrees using wedge pillow or bed risers

Screening

  • symptoms of gastroesophageal reflux disease Moderate

    rs10987077 risk variant is associated with GERD susceptibility in large-scale genetic studies

    monitor for heartburn, regurgitation, dysphagia, and chest discomfort