rs10986603 - PPP6C
Magnitude 2.2 · 1 study on file
Reported associations
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Identifying genetic loci and phenomic associations of substance use traits: A multi-trait analysis of GWAS (MTAG) study - Unknown journal (n.d.) · Unknown authors · PubMed 37156939
ABSTRACT: Background and Aims: Genome-wide association studies (GWAS) of opioid use disorder (OUD) and cannabis use disorder (CUD) have lagged behind those of alcohol use disorder (AUD) and smoking, where many more loci have been identified. We sought to identify novel loci for substance use traits (SUTs) in both African- (AFR) and European- (EUR) ancestry individuals to enhance our understanding of the traits' genetic architecture. Design: We used multi-trait analysis of GWAS (MTAG) to analyze four SUTs in EUR subjects (OUD, CUD, AUD and smoking initiation [SMKinitiation]), and three SUTs in AFR subjects (OUD, AUD and smoking trajectory [SMKtrajectory]). We conducted gene-set and protein-protein interaction analyses and calculated polygenic risk scores (PRS) in two independent samples
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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genetic predisposition to substance use disorders High
rs10986603 is strongly associated with opioid use disorder risk (p=5e-12) and alcohol use disorder risk (p=2e-11)
Lifestyle
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limiting alcohol consumption High
genetic variant increases susceptibility to alcohol use disorder (p=2e-11); reduced consumption lowers exposure-dependent risk
establish personal daily or weekly alcohol limits and monitor consumption patterns
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unnecessary opioid exposure High
genetic variant substantially increases opioid use disorder risk; minimizing exposure reduces behavioral addiction risk
request non-opioid pain management alternatives; discuss minimization strategies with provider before any opioid use