rs10986471 - ARPC5L

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide meta-analyses of cross substance use disorders in diverse populations. - Molecular psychiatry (2026) · Lai D, Zhang M, Green N, Abreu M, Schwantes-An TH, Parker CC, Zhang S, Jin F, Sun A, Zhang P, Edenberg HJ, Liu Y, Foroud T · PubMed 41057643

  Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent significant public health challenges. The estimated heritability of SUDs is ~50% and many individuals experience multiple SUDs concurrently. Studies have demonstrated the existence of genes shared across multiple SUDs, and identifying these SUD-shared genes is critical to developing novel prevention and treatment strategies. Here, we conducted the largest cross SUD meta-analysis to date to identify SUD-shared genes using samples genetically similar to 1000 Genomes Project European (1kg-EUR-like), African (1kg-AFR-like), and American mixed (1kg-AMR-like) populations. We defined variants that had the same direction of effects across different SUDs (i.e., concordant variants) as SUD-shared. In total, w

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