rs10986291 - LHX2 - NEK6
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma - Unknown journal (n.d.) · Unknown authors · PubMed 32296059
ABSTRACT: Asthma is a chronic and genetically complex respiratory disease that affects over 300 million people worldwide. Here, we report a genome-wide analysis for asthma using data from the UK Biobank and the Trans-National Asthma Genetic Consortium. We identify 66 previously unknown asthma loci and demonstrate that the susceptibility alleles in these regions are, either individually or as a function of cumulative genetic burden, associated with risk to a greater extent in men than women. Bioinformatics analyses prioritize candidate causal genes at 52 loci, including CD52, and demonstrate that asthma-associated variants are enriched in regions of open chromatin in immune cells. Lastly, we show that a murine anti-CD52 antibody mimics the immune cell-depleting effects of a clinically used
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Screening
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pulmonary function testing and respiratory assessment Moderate
Genetic variant associated with increased asthma risk (1.037-fold per allele in well-powered GWAS)
Annual spirometry and symptom screening, or earlier if respiratory symptoms develop