Expressive

rs10984561 - BRINP1 - LINC01613

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide association study of lung function decline in adults with and without asthma - Unknown journal (n.d.) · Unknown authors · PubMed 22424883

    ABSTRACT: Background Genome-wide association studies (GWAS) have identified determinants of chronic obstructive pulmonary disease, asthma and lung function level, however none addressed decline in lung function. Aim We conducted the first GWAS on age-related decline in forced expiratory volume in the first second (FEV1) and in its ratio to forced vital capacity (FVC) stratified a priori by asthma status. Methods Discovery cohorts included adults of European ancestry (1441 asthmatics, 2677 non-asthmatics; Epidemiological Study on the Genetics and Environment of Asthma (EGEA); Swiss Cohort Study on Air Pollution And Lung And Heart Disease In Adults (SAPALDIA); European Community Respiratory Health Survey (ECRHS)). The associations of FEV1 and FEV1/FVC decline with 2.5 million single nucleoti

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Exercise

  • Regular aerobic exercise Moderate

    Aerobic activity supports pulmonary health and may help maintain function in those at genetic risk for decline

    150 minutes moderate-intensity aerobic activity per week

Lifestyle

  • Tobacco and air pollution exposure Moderate

    Smoking and air pollution accelerate pulmonary function decline in genetically susceptible individuals

Screening

  • Pulmonary function testing Moderate

    rs10984561 associates with pulmonary function decline; baseline and periodic testing can detect and monitor progression

    Obtain baseline FEV1/FVC and FEV1; repeat every 2-3 years