Expressive

rs10983778 - TLR4 - TPT1P9

Magnitude 4.5 · 1 study on file

Reported associations

  • Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways. - Nature genetics (2019) · Nagel M, Jansen PR, Stringer S, Watanabe K, de Leeuw CA, Bryois J, Savage JE, Hammerschlag AR, Skene NG, Muñoz-Manchado AB, White T, Tiemeier H, Linnarsson S, Hjerling-Leffler J, Polderman TJC, Sullivan PF, van der Sluis S, Posthuma D · PubMed 29942085

    Neuroticism is an important risk factor for psychiatric traits, including depression , anxiety , and schizophrenia . At the time of analysis, previous genome-wide association studies (GWAS) reported 16 genomic loci associated to neuroticism . Here we conducted a large GWAS meta-analysis (n = 449,484) of neuroticism and identified 136 independent genome-wide significant loci (124 new at the time of analysis), which implicate 599 genes. Functional follow-up analyses showed enrichment in several brain regions and involvement of specific cell types, including dopaminergic neuroblasts (P = 3.49 × 10 ), medium spiny neurons (P = 4.23 × 10 ), and serotonergic neurons (P = 1.37 × 10 ). Gene set analyses implicated three specific pathways: neurogenesis (P = 4.43

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • Regular stress management or mindfulness practice Moderate

    Neuroticism-associated emotional reactivity benefits from structured stress-reduction practices that improve emotional regulation.

    Practice 15-30 minutes daily mindfulness, meditation, or relaxation techniques.

  • Sleep quality and duration Moderate

    Sleep deprivation exacerbates neuroticism-related emotional reactivity and increases anxiety/depression risk.

    Maintain 7-9 hour consistent sleep schedule; track sleep quality and address insomnia promptly.

Screening

  • Mental health assessment for anxiety and depression Moderate

    Genetic association with neuroticism predicts increased risk for anxiety and depression; early detection improves outcomes.

    Discuss anxiety/depression screening with healthcare provider; consider PHQ-9 and GAD-7 assessments.