rs10982287 - WHRN - ATP6V1G1

Magnitude 2.0 · 1 study on file

Reported associations

• Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche. - The Journal of clinical endocrinology and metabolism (2016) · Tan LJ, Wang ZE, Wu KH, Chen XD, Zhu H, Lu S, Tian Q, Liu XG, Papasian CJ, Deng HW · PubMed 26312577

  Age at menarche (AAM) is determined by the overall duration of endocrine-tissue sex hormone exposure levels. Osteoporosis, the most common metabolic bone disease, is characterized primarily by reduced bone mineral density (BMD) and an increased risk of low trauma fractures. Bone was an endocrine organ regulating the synthesis and secretion of sex steroid hormones. The mutual dependence between bone and gonads underscore the importance of genetic approaches to identify novel pleiotropic genetic factors coregulating BMD and AAM. In this study, we performed a bivariate genome-wide association study (GWAS) to explore novel ethnic common loci and/or genes that may influence both AAM and BMD. We analyzed genotyping data available for 826 unrelated Chinese subjects using genome-wide human genotyp

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