rs10979314 - CHCHD4P2 - RPL36P14
Magnitude 4.5 · 1 study on file
Reported associations
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Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease - Unknown journal (n.d.) · Unknown authors · PubMed 27082954
ABSTRACT: There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes, potentially by increasing susceptibility to these exposures. However, genome-scale investigations of these interactions have been rarely performed particularly in the case of air pollution exposures. We performed race-stratified genome-wide gene-environment interaction association studies on European-American (EA, N = 1623) and African-American (AA, N = 554) cohorts to investigate the joint influence of common single nucleotide polymorphisms (SNPs) and residential exposure to traffic ("traffic exposure")-a recognized vascular disease risk factor-on peripheral arterial disease (PAD). Traffic exposure was estimated via the dis
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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PAD risk given rs10979314 status Moderate
rs10979314 strongly associates with peripheral artery disease, particularly with traffic air pollution exposure
Review genotype and baseline PAD screening strategy
Lifestyle
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High-traffic air pollution exposure Moderate
PAD risk from rs10979314 is elevated in context of traffic-related air pollution
Minimize time near highways and high-traffic areas; monitor daily air quality
Screening
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Peripheral artery disease screening Moderate
rs10979314 associates with increased peripheral artery disease risk
Baseline ultrasound or ankle-brachial index testing