Expressive

rs10975488 - GTF3AP1 - IL33

Magnitude 2.2 · 1 study on file

Reported associations

  • Detection and interpretation of shared genetic influences on 42 human traits - Unknown journal (n.d.) · Unknown authors · PubMed 27182965

    ABSTRACT: We performed a scan for genetic variants associated with multiple phenotypes by comparing large genome-wide association studies (GWAS) of 42 traits or diseases. We identified 341 loci (at an FDR of 10%) associated with multiple traits. Several loci are associated with a large number of phenotypes; for example, a nonsynonymous variant in the zinc transporter SLC39A8 influences seven of these traits, including risk of schizophrenia (rs13107325: log-odds ratio = 0.15, P = 2 × 10−12) and Parkinson's disease (log-odds ratio = −0.15, P = 1.6 × 10−7), among others. Second, we used these loci to identify traits that share multiple genetic causes in common. For example, variants that increase risk of schizophrenia also tend to increase risk of inflammatory bowel disease. Finally,

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • personalized allergy risk assessment and planning Moderate

    rs10975488 increases allergy susceptibility, warranting professional guidance on prevention and management

    discuss genetic allergy risk with your doctor or allergist for personalized prevention strategies

Lifestyle

  • allergic symptoms and reaction patterns Moderate

    increased genetic susceptibility to allergies requires heightened awareness of symptom onset and patterns

    track timing, triggers, severity of sneezing, congestion, itching, rash, or other allergic symptoms

Screening

  • allergy testing and skin prick testing Moderate

    rs10975488 increases allergy susceptibility via IL33 immune pathway, increasing risk of environmental allergies

    discuss with allergist to arrange comprehensive allergy testing if not recently done