Expressive

rs10975467 - RANBP6 - GTF3AP1

Magnitude 2.2 · 2 studies on file

Reported associations

  • Improved genetic discovery and fine-mapping resolution through multivariate latent factor analysis of high-dimensional traits - Unknown journal (n.d.) · Unknown authors · PubMed 40220762

    ABSTRACT: Summary Genome-wide association studies (GWASs) of high-dimensional traits, such as blood cell or metabolic traits, often use univariate approaches, ignoring trait relationships. Biological mechanisms generating variation in high-dimensional traits can be captured parsimoniously through a GWAS of latent factors. Here, we introduce flashfmZero, a zero-correlation latent-factor-based multi-trait fine-mapping approach. In an application to 25 latent factors derived from 99 blood cell traits in the INTERVAL cohort, we show that latent factor GWASs enable the detection of signals generating sub-threshold associations with several blood cell traits. The 99% credible sets (CS99) from flashfmZero were equal to or smaller in size than those from univariate fine-mapping of blood cell trait

  • Genetic architecture of asthma in African American Patients - Unknown journal (n.d.) · Unknown authors · PubMed 36089080

    ABSTRACT: Background: Asthma is a chronic inflammatory disorder with a strong genetic inheritance. Although over one hundred loci were reported through the genome-wide association study of European populations, the genetic underpinning of asthma in African Americans remains largely elusive. Objective: We aimed to identify genetic loci associated with asthma in African Americans. Methods: Three cohorts were genotyped at the Children's Hospital of Philadelphia (CHOP) using the Illumina SNP array platform. Genotype imputation was performed using the TOPMed reference panel including whole genome sequencing data from over 100,000 individuals. Meta-analysis of three CHOP cohorts and ten CAAPA cohorts totaling 19,628 subjects was conducted to identify genetic loci associated with asthma in Afri

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