rs10975416 - RANBP6 - GTF3AP1
Magnitude 2.2 · 1 study on file
Reported associations
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Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis. - The European respiratory journal (2020) · Zhu Z, Zhu X, Liu CL, Shi H, Shen S, Yang Y, Hasegawa K, Camargo CA, Liang L · PubMed 31619474
Epidemiological studies demonstrate an association between asthma and mental health disorders, although little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetics and the causal link between asthma and mental health disorders.We conducted a large-scale genome-wide cross-trait association study to investigate genetic overlap between asthma from the UK Biobank and eight mental health disorders from the Psychiatric Genomics Consortium: attention deficit hyperactivity disorder (ADHD), anxiety disorder (ANX), autism spectrum disorder, bipolar disorder, eating disorder, major depressive disorder (MDD), post-traumatic stress disorder and schizophrenia (sample size 9537-394 283).In the single-trait genome-wide association analysis,
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Discuss asthma risk with healthcare provider Moderate
Genetic risk variant identified via GWAS; early clinical assessment supports prevention and management planning.
Screening
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Monitor for asthma symptoms Moderate
Rs10975416 risk allele increases asthma risk (OR 1.104, p=5e-36); early symptom detection enables prompt diagnosis and treatment.
Report cough, shortness of breath, chest tightness, or wheezing to healthcare provider