rs10966811 - RN7SKP120 - TUSC1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study identifies candidate genes for male fertility traits in humans. - American journal of human genetics (2012) · Kosova G, Scott NM, Niederberger C, Prins GS, Ober C · PubMed 22633400

  Despite the fact that hundreds of genes are known to affect fertility in animal models, relatively little is known about genes that influence natural fertility in humans. To broadly survey genes contributing to variation in male fertility, we conducted a genome-wide association study (GWAS) of two fertility traits (family size and birth rate) in 269 married men who are members of a founder population of European descent that proscribes contraception and has large family sizes. Associations between ∼250,000 autosomal SNPs and the fertility traits were examined. A total of 41 SNPs with p ≤ 1 × 10(-4) for either trait were taken forward to a validation study of 123 ethnically diverse men from Chicago who had previously undergone semen analyses. Nine (22%) of the SNPs associated with redu

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