rs10966259 - VLDLR-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome‐wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway - Unknown journal (n.d.) · Unknown authors · PubMed 29532581

  ABSTRACT: Abstract The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowledge of the underlying genetic architecture remains meager. Our aim was to identify novel genetic variants responsible for interindividual differences in smoking behavior. We performed a genome‐wide association study on 1715 ever smokers ascertained from the population‐based Finnish Twin Cohort enriched for heavy smoking. Data imputation used the 1000 Genomes Phase I reference panel together with a whole genome sequence‐based Finnish reference panel. We analyzed three measures of nicotine addiction-smoking quantity, nicotine dependence and nicotine withdrawal. We annotated all genome‐wide significant SNPs for their functional potential. First, we detected genome

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