rs10965522 - VLDLR-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of white-coat effect in hypertensive patients. - Blood pressure (2019) · Rimpelä JM, Niiranen T, Jula A, Pörsti IH, Tikkakoski A, Havulinna A, Lehtimäki T, Salomaa V, Kontula KK, Hiltunen TP · PubMed 31044621

  White-coat effect (WCE) confounds diagnosis and treatment of hypertension. The prevalence of white-coat hypertension is higher in Europe and Asia compared to other continents suggesting that genetic factors could play a role. To study genetic variation affecting WCE, we conducted a two-stage genome-wide association study involving 1343 Finnish subjects. For the discovery stage, we used Genetics of Drug Responsiveness in Essential Hypertension (GENRES) cohort ( = 206), providing the mean WCE values from up to four separate office/ambulatory recordings conducted on placebo. Associations with values <1 × 10 were included in the replication step in three independent cohorts: Haemodynamics in Primary and Secondary Hypertension (DYNAMIC) ( = 182), Finn-Home study ( = 773) and Dietary,

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