rs10965227 - CDKN2B-AS1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study of cardiometabolic multimorbidity in the UK Biobank. - Clinical genetics (2024) · Zhao C, Ma T, Cheng X, Zhang G, Bai Y · PubMed 38409652

  Considering the high prevalence and poor prognosis of cardiometabolic multimorbidity (CMM), identifying causal factors and actively implementing preventive measures is crucial. However, Mendelian randomization (MR), a key method for identifying the causal factors of CMM, requires knowledge of the effects of SNPs on CMM, which remain unknown. We first analyzed the genetic overlap of single cardiometabolic diseases (CMDs) using the latest genome-wide association study (GWAS) for evidential support and comparison. We observed strong positive genetic correlations and shared loci among all CMDs. Further, GWAS and post-GWAS analyses of CMM were performed in 407 949 European ancestry individuals from the UK Biobank. Eleven loci and 12 lead SNPs were identified. By comparison, we found these SNP

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