rs10963767 - ADAMTSL1

Magnitude 2.2 · 1 study on file

Reported associations

• Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study. - Endocrine journal (2024) · Li Y, Yang M, Yuan L, Li T, Zhong X, Guo Y · PubMed 37779084

  Our objective was to construct a polygenic risk score (PRS) and assess its utility and effectiveness in predicting the risk of gestational diabetes mellitus (GDM) in a Chinese population. We performed a case-control study involving 638 patients with GDM and 1,062 healthy controls. Genotyping was conducted utilizing a genome-wide association study (GWAS), and a PRS was constructed. We identified 12 susceptibility loci that exhibited significant associations with the risk of GDM at a p-value threshold of ≤5.0 × 10 , of which four loci were newly discovered. A higher PRS was associated with an increased risk of GDM (OR: 1.44; 95% CI: 1.03, 2.01 for the highest quartile compared to the lowest quartile). The PRS demonstrated a clear linear relationship with the fasting plasma glucose (FPG),

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