Expressive

rs10962650 - BNC2 - RN7SL720P

Magnitude 2.2 · 1 study on file

Reported associations

  • Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449

    ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • personalized skin cancer risk and prevention plan High

    Genetic variant rs10962650-C increases skin cancer susceptibility based on large GWAS study

    Review personal and family history of skin cancer, establish individualized screening and prevention strategy

Lifestyle

  • comprehensive sun protection behavior High

    C-allele carriers show elevated skin cancer susceptibility requiring proactive UV avoidance strategies

    Daily SPF 30+ sunscreen, limit sun exposure 10am-4pm, wear UV-protective clothing when outdoors

Screening

  • annual dermatological skin cancer screening High

    rs10962650-C allele associated with significantly increased skin cancer risk across 610726 participants

    Annual full-body skin examination with dermatologist; earlier/more frequent if family history of skin cancer