Expressive

rs10962563 - BNC2

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • heavy lifting Moderate

    Heavy lifting increases intra-abdominal pressure; individuals with genetic predisposition should minimize this modifiable risk factor

    When possible, distribute load, use equipment, or ask for assistance with objects over 25 pounds

  • proper lifting technique training Moderate

    Genetic predisposition increases vulnerability to abdominal wall strain; minimizing pressure spikes through technique is especially important

    Use leg muscles not back; avoid twisting while lifting; practice core engagement during heavy activities

Screening

  • inguinal hernia risk assessment Moderate

    BNC2 genetic variant increases inguinal hernia risk; clinical assessment enables early detection and prevention

    Discuss with physician at next visit; report any groin pain, swelling, or bulging