rs10960680 - RNU2-47P - LURAP1L-AS1

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of psoriasis in an Egyptian population. - Experimental dermatology (2020) · Bejaoui Y, Witte M, Abdelhady M, Eldarouti M, Abdallah NMA, Elghzaly AA, Tawhid Z, Gaballah MA, Busch H, Munz M, Wendorff M, Ellinghaus E, Franke A, Ibrahim SM · PubMed 30921485

  Psoriasis is a chronic inflammatory disorder of the skin, with genetic factors reportedly involved in the disease pathogenesis. Numerous studies reported psoriasis candidate genes. However, these tend to involve mostly in the European and Asian populations. Here, we report the first genome-wide association study (GWAS) in an Egyptian population, identifying susceptibility variants for psoriasis using a two-stage case-control design. In the first discovery stage, we carried out a genome-wide association analysis using the Infinium Global Screening Array-24 v1.0, on 253 cases and 449 control samples of Egyptian descent. In the second replication stage, 26 single-nucleotide polymorphisms (SNPs) were selected for replication in additional 321 cases and 253 controls. In concordance with the fin

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