Expressive

rs10960103 - LINC03131 - JKAMPP1

Magnitude 2.2 · 4 studies on file

Reported associations

  • Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways - Unknown journal (n.d.) · Unknown authors · PubMed 29662059

    ABSTRACT: Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10−8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in

  • Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism - Unknown journal (n.d.) · Unknown authors · PubMed 29255261

    ABSTRACT: Neuroticism is a relatively stable personality trait characterised by negative emotionality (e.g., worry, guilt); twin study heritability ranges 30 to 50%, and SNP-based heritability ranges 6 to 15%. Increased neuroticism is associated with poorer mental and physical health, translating to high economic burden. Genome-wide association (GWA) studies of neuroticism have identified up to 11 genetic loci. Here we report 116 significant independent loci from a GWA of neuroticism in 329,821 UK Biobank participants; 15 of these replicated at P<.00045 in an unrelated cohort (N = 122,867). Genetic signals were enriched in neuronal genesis and differentiation pathways, and substantial genetic correlations were found between neuroticism and depressive symptoms (rg = .82, SE=.03), major depr

  • Multivariate genome-wide analysis of education, socioeconomic status, and brain phenome - Unknown journal (n.d.) · Unknown authors · PubMed 33349686

    ABSTRACT: Socioeconomic status (SES) and education (EDU) are phenotypically associated with psychiatric disorders and behaviors. It remains unclear how these associations influence genetic risk for psychopathology, psychosocial factors, and EDU/SES individually. Using information from >1 million individuals, we conditioned the genetic risk for psychiatric disorders, personality traits, brain imaging phenotypes, and externalizing behaviors with genome-wide data for EDU/SES. Accounting for EDU/SES significantly affected the observed heritability of psychiatric traits ranging from 2.44% h2 decrease for bipolar disorder to 14.2% h2 decrease for Tourette syndrome. Neuroticism h2 significantly increased by 20.23% after conditioning with SES. After EDU/SES conditioning, neuronal cell-types were i

  • Genetic variants associated with subjective well-being, depressive symptoms and neuroticism identified through genome-wide analyses - Unknown journal (n.d.) · Unknown authors · PubMed 27089181

    ABSTRACT: We conducted genome-wide association studies of three phenotypes: subjective well-being (N = 298,420), depressive symptoms (N = 161,460), and neuroticism (N = 170,910). We identified three variants associated with subjective well-being, two with depressive symptoms, and eleven with neuroticism, including two inversion polymorphisms. The two depressive symptoms loci replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes strengthen the overall credibility of the findings, and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal/pancreas tissues are strongly enriched for association. FULL TEXT: [INTRO] Introduction [INTRO] Subjectiv

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