rs10959883 - LINC03131 - JKAMPP1

Magnitude 2.2 · 1 study on file

Reported associations

• A Major Role for Common Genetic Variation in Anxiety Disorders - Unknown journal (n.d.) · Unknown authors · PubMed 31748690

  ABSTRACT: Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (ncase=25 453, ncontrol=58 113) and an additional analysis of Current Anxiety Symptoms (ncase= 19 012, ncontrol= 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from

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