rs10958998 - PTPRD
Magnitude 2.2 · 1 study on file
Reported associations
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Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries - Unknown journal (n.d.) · Unknown authors · PubMed 24556642
ABSTRACT: Dental caries continues to be the most common chronic disease in children today. Despite the substantial involvement of genetics in the process of caries development, the specific genes contributing to dental caries remain largely unknown. We performed separate genome-wide association studies of smooth and pit-and-fissure tooth surface caries experience in the primary dentitions of self-reported white children in two samples from Iowa and rural Appalachia. In total, 1006 children (ages 3-12 years) were included for smooth surface analysis, and 979 children (ages 4-14 years) for pit-and-fissure surface analysis. Associations were tested for more than 1.2 million single nucleotide polymorphisms, either genotyped or imputed. We detected genome-wide significant signals in KPNA4 (p-va
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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dental sealants on posterior molars Moderate
Sealants block occlusal pits and fissures where caries initiate in susceptible individuals
Apply to first molars at eruption (age 6), second molars (age 12); reapply if deteriorated
Screening
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dental caries risk assessment starting at age 6 Moderate
PTPRD rs10958998-A increases susceptibility to pit-and-fissure caries
Professional dental exam every 6 months; assess caries risk and enamel quality