rs10957077 - TOX

Magnitude 2.2 · 1 study on file

Reported associations

• Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort - Unknown journal (n.d.) · Unknown authors · PubMed 34624637

  ABSTRACT: Highlights The voxel-wise comparison between older adults with hearing loss and without hearing loss revealed FDG hypometabolism in bilateral Heschl's gyrus. Additional FDG hypometabolism in the inferior colliculus and cochlear nucleus was localized after age-adjustment. Decline in FDG metabolism in the cochlear nucleus was accelerated in people with hearing loss. Various genetic loci demonstrated suggestive associations with glucose metabolism in hearing loss-associated brain regions. Purpose Hearing loss (HL) is one of the most common age-related diseases. Here, we investigate the central auditory correlates of HL in people with normal cognition and mild cognitive impairment (MCI) and test their association with genetic markers with the aim of revealing pathogenic mechanisms.

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