rs1095626 - RSRC1

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions - Unknown journal (n.d.) · Unknown authors · PubMed 30718901

  ABSTRACT: Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximise sample size, we meta-analysed data on 807,553 individuals (246,363 cases and 561,190 controls) from the three largest genome-wide association studies of depression. We identified 102 independent variants, 269 genes, and 15 gene-sets associated with depression, including both genes and gene-pathways associated with synaptic structure and neurotransmission. An enrichment analysis provided further evidence of the importance of prefrontal brain regions. In an independent replication sample of 1,306,354 individuals

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