rs10953615 - BUB3P1 - EIF3IP1

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. - Journal of human genetics (2012) · Cha PC, Zembutsu H, Takahashi A, Kubo M, Kamatani N, Nakamura Y · PubMed 22318345

  Gallbladder cancer (GC) is a relatively uncommon cancer with higher incidence in certain areas including Japan. Because of the difficulty in diagnosis, prognosis of GC is very poor. To identify genetic determinants of GC, we conducted a genome-wide association study (GWAS) in 41 GC patients and 866 controls. Association between each single-nucleotide polymorphism (SNP) with GC susceptibility was evaluated by multivariate logistic regression analysis conditioned on age and gender of subjects. SNPs that showed suggestive association (P<1 × 10(-4)) with GC were further examined in 30 cases and 898 controls. SNP rs7504990 in the DCC (deleted in colorectal cancer, 18q21.3) that encodes a netrin 1 receptor achieved a combined P-value of 7.46 × 10(-8) (OR=6.95; 95% CI=3.43-14.08). Subsequent im

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