rs10953513 - POM121C
Magnitude 2.2 · 1 study on file
Reported associations
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Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program - Unknown journal (n.d.) · Unknown authors · PubMed 39024449
ABSTRACT: INTRODUCTION: Findings from genome-wide association studies (GWASs) have provided foundational knowledge of the genetic basis of disease, facilitating precision approaches for prevention and treatment. Current GWAS results are limited by underrepresentation of individuals from diverse populations, leading to concerns with generalizability regarding our knowledge of the relationships between genes, traits, and disease. The Department of Veterans Affairs (VA) Million Veteran Program (MVP), one of the largest US-based biobanks, addresses this need; 29% of MVP comprises individuals genetically similar to African (AFR), Admixed American (AMR), and East Asian (EAS) reference populations. With over 635,000 participants and more than 44.3M genotyped variants linked with detailed phenotyp
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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BMI and weight trend monitoring Moderate
rs10953513-A is associated with higher BMI (p=6e-20) and weight (p=2e-18) in large GWAS cohorts
Target BMI less than 25; check quarterly or when weight changes more than 5 pounds
Screening
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blood pressure screening starting age 25-30 Moderate
rs10953513-A is associated with significantly elevated hypertension risk (p=2e-14, n=428,138)
Annual screening minimum; more frequent if baseline elevated or family history present