rs10948800 - NOL7, RANBP9

Magnitude 2.0 · 1 study on file

Reported associations

• Using human genetics to understand the phenotypic association between chronotype and breast cancer. - Journal of sleep research (2024) · Wu X, Yang C, Zou Y, Jones SE, Zhao X, Zhang L, Han Z, Hao Y, Xiao J, Xiao C, Zhang W, Yan P, Cui H, Tang M, Wang Y, Chen L, Zhang L, Yao Y, Liu Z, Li J, Jiang X, Zhang B · PubMed 37380357

  Little is known regarding the shared genetic influences underlying the observed phenotypic association between chronotype and breast cancer in women. Leveraging summary statistics from the hitherto largest genome-wide association study conducted in each trait, we investigated the genetic correlation, pleiotropic loci, and causal relationship of chronotype with overall breast cancer, and with its subtypes defined by the status of oestrogen receptor. We identified a negative genomic correlation between chronotype and overall breast cancer ( = -0.06, p = 3.00 × 10 ), consistent across oestrogen receptor-positive ( = -0.05, p = 3.30 × 10 ) and oestrogen receptor-negative subtypes ( = -0.05, p = 1.11 × 10 ). Five specific genomic regions were further identified

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