rs10947260 - TSBP1-AS1, BTNL2

Magnitude 2.2 · 1 study on file

Reported associations

• Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease - Unknown journal (n.d.) · Unknown authors · PubMed 28369058

  ABSTRACT: Recent advances in highly multiplexed immunoassays have allowed systematic large-scale measurement of hundreds of plasma proteins in large cohort studies. In combination with genotyping, such studies offer the prospect to 1) identify mechanisms involved with regulation of protein expression in plasma, and 2) determine whether the plasma proteins are likely to be causally implicated in disease. We report here the results of genome-wide association (GWA) studies of 83 proteins considered relevant to cardiovascular disease (CVD), measured in 3,394 individuals with multiple CVD risk factors. We identified 79 genome-wide significant (p<5e-8) association signals, 55 of which replicated at P<0.0007 in separate validation studies (n = 2,639 individuals). Using automated text mining, manu

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