rs10946793 - SCGN
Magnitude 4.5 · 1 study on file
Reported associations
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Genome-wide association meta-analysis identifies two novel loci associated with dental caries - Unknown journal (n.d.) · Unknown authors · PubMed 39192244
ABSTRACT: Background Tooth loss significantly impacts oral function and overall health deterioration. Dental caries and periodontal disease are major contributors to tooth loss, emphasizing the critical need to prevent these conditions. Genetic studies have played a crucial role in deepening our understanding of the underlying mechanisms of these diseases. While large-scale genome-wide association studies (GWAS) on dental caries and periodontal disease have been conducted extensively, research focusing on Asian populations remains limited. Given substantial genetic and lifestyle variations across ethnicities, conducting studies across diverse populations is imperative. This study aimed to uncover new insights into the genetic mechanisms of these diseases, contributing to broader knowledge
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Diet
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excess dietary sugars and acidic beverages Moderate
Genetic susceptibility to caries suggests heightened response to dietary cariogenic substrates; reducing sugar exposure is especially important for individuals at genetic risk.
Limit added sugars to less than 10% of daily calories; reduce frequency of acidic beverage consumption
Screening
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dental health monitoring for caries risk Moderate
rs10946793 shows strong GWAS association with dental caries (p=3.00e-13), indicating increased biological susceptibility to tooth decay.
Schedule dental exams every 6 months; discuss caries prevention strategies with dentist