rs10937664 - EVC

Magnitude 2.2 · 1 study on file

Reported associations

• Genetics of osteonecrosis in children and adults with systemic lupus erythematosus. - Rheumatology (Oxford, England) (2023) · Webber D, Cao J, Dominguez D, Gladman DD, Knight A, Levy DM, Liao F, Ng L, Paterson AD, Touma Z, Wither J, Urowitz M, Silverman ED, Hiraki LT · PubMed 36651668

  Genetics plays an important role in SLE risk, as well as osteonecrosis (ON), a significant and often debilitating complication of SLE. We aimed to identify genetic risk loci for ON in people with childhood-onset (cSLE) and adult-onset (aSLE) SLE. We enrolled participants from two tertiary care centres who met classification criteria for SLE. Participants had prospectively collected clinical data and were genotyped on a multiethnic array. Un-genotyped single nucleotide polymorphisms (SNPs) were imputed, and ancestry was inferred using principal components (PCs). Our outcome was symptomatic ON confirmed by imaging. We completed time-to-ON and logistic regression of ON genome-wide association studies (GWASs) with covariates for sex, age of SLE diagnosis, five PCs for ancestry, corticosteroid

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