Expressive

rs10937208 - C3orf70 - EHHADH-AS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 32541925

    ABSTRACT: We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ethnic meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program, DIAMANTE, Biobank Japan, and other studies. We report 568 associations, including 286 autosomal, 7 X chromosomal, and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected 3,568 T2D-associations with genetically predicted gene expression in 687 novel genes; of these, 54 are known to interact with FDA-approved drugs. A polygenic risk score was strongly associated with increased risk of T2D-related retinopathy and modestly associated with chronic kidney disease (CKD), peripheral artery disease (PAD), and neuropathy. We investigated the genetic etiolo

Auto-generated from study metadata. AI-synthesised commentary is added when this entry is regenerated through content-service's LLM mode.

Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • Lower glycemic-index carbohydrates Moderate

    Reduced glucose spikes from low glycemic foods improve metabolic flexibility and decrease Type 2 diabetes risk

    Emphasize whole grains, legumes, non-starchy vegetables; limit refined sugars and white-flour products

Exercise

  • Regular aerobic and resistance exercise Moderate

    Physical activity improves insulin sensitivity and glucose tolerance, counteracting Type 2 diabetes genetic risk

    150 minutes moderate intensity aerobic activity weekly; resistance training 2 times per week

Lifestyle

  • Maintain healthy weight and body composition Moderate

    Excess adiposity amplifies insulin resistance and Type 2 diabetes risk; weight loss improves metabolic phenotype

    Track weight and waist circumference; maintain waist circumference below 40 inches (men) or 35 inches (women)

Screening

  • Glucose and HbA1c screening Moderate

    Type 2 diabetes risk allele requires metabolic surveillance to enable early intervention

    Annual laboratory assessment; earlier if overweight or family history