rs10935768 - ARHGEF28P1 - COL8A1

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican-Americans: The GUARDIAN Consortium. - Obesity (Silver Spring, Md.) (2020) · Young KA, Palmer ND, Fingerlin TE, Langefeld CD, Norris JM, Wang N, Xiang AH, Guo X, Williams AH, Chen YI, Taylor KD, Rotter JI, Raffel LJ, Goodarzi MO, Watanabe RM, Wagenknecht LE · PubMed 31219225

  ABSTRACT: Objective: Mexican-American ancestry populations are at increased risk of non-alcoholic fatty liver disease (NALFD). Our objective was to determine whether loci in known and novel genes were associated with variation of aspartate aminotransferase (AST, n=3644), alanine aminotransferase (ALT, n=3595) and gamma-glutamyl transferase (GGT, n=1577) by conducting the first genome-wide association study (GWAS) of liver enzymes, which commonly measure liver function, in Mexican-American ancestry. Methods: Levels of AST, ALT, and GGT were determined by enzymatic colorimetric assays. A multi-cohort Mexican-American ancestry GWAS was performed. SNPs were tested for association with liver outcomes by multivariable linear regression using an additive genetic model. Association analyses were c

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