Expressive

rs1093462 - LSAMP - IGSF11

Magnitude 2.2 · 1 study on file

Reported associations

  • Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. - Nature genetics (2022) · Watanabe K, Jansen PR, Savage JE, Nandakumar P, Wang X, Hinds DA, Gelernter J, Levey DF, Polimanti R, Stein MB, Van Someren EJW, Smit AB, Posthuma D · PubMed 35835914

    Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment currently exists. Previous genome-wide association studies with up to 1.3 million subjects identified over 200 associated loci. This extreme polygenicity suggested that many more loci remain to be discovered. The current study almost doubled the sample size to 593,724 cases and 1,771,286 controls, thereby increasing statistical power, and identified 554 risk loci (including 364 novel loci). To capitalize on this large number of loci, we propose a novel strategy to prioritize genes using external biological resources and functional interactions between genes across risk loci. Of all 3,898 genes naively implicated from the risk loci, we prioritize 289 and find brain-tissue expression spec

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Discuss with your doctor

  • Genetic predisposition to insomnia Moderate

    Strong GWAS evidence demonstrates T allele association with insomnia; proactive discussion enables early intervention if needed

    Discuss sleep history, symptoms, and prevention strategies

Lifestyle

  • Sleep hygiene optimization Moderate

    T allele carriers have genetic predisposition to insomnia; consistent sleep schedule and environment optimization can mitigate risk

    Maintain regular sleep schedule, limit caffeine after 2pm, keep bedroom cool and dark

Screening

  • Sleep quality and insomnia symptoms Moderate

    T allele at rs1093462 is associated with increased insomnia risk in a large GWAS study of 2.36 million individuals

    Monitor sleep duration and quality; discuss any sleep concerns with healthcare provider