rs10934447 - LSAMP - IGSF11

Magnitude 2.2 · 1 study on file

Reported associations

• Genome-wide association study identifies novel locus for neuroticism and shows polygenic association with Major Depressive Disorder - Unknown journal (n.d.) · Unknown authors · PubMed 25993607

  ABSTRACT: Importance Neuroticism is a personality trait that is briefly defined by emotional instability. It is a robust genetic risk factor for Major Depressive Disorder (MDD) and other psychiatric disorders. Hence, neuroticism is an important phenotype for psychiatric genetics. The Genetics of Personality Consortium (GPC) has created a resource for genome-wide association analyses of personality traits in over 63,000 participants (including MDD cases). Objective To identify genetic variants associated with neuroticism by performing a meta-analysis of genome-wide association (GWA) results based on 1000Genomes imputation, to evaluate if common genetic variants as assessed by Single Nucleotide Polymorphisms (SNPs) explain variation in neuroticism by estimating SNP-based heritability, and to

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