Expressive

rs10931284 - CALCRL-AS1, CALCRL

Magnitude 2.2 · 3 studies on file

Reported associations

  • Genome-wide association study of medication-use and associated disease in the UK Biobank - Unknown journal (n.d.) · Unknown authors · PubMed 31015401

    ABSTRACT: Genome-wide association studies (GWASs) of medication use may contribute to understanding of disease etiology, could generate new leads relevant for drug discovery and can be used to quantify future risk of medication taking. Here, we conduct GWASs of self-reported medication use from 23 medication categories in approximately 320,000 individuals from the UK Biobank. A total of 505 independent genetic loci that meet stringent criteria (P < 10−8/23) for statistical significance are identified. We investigate the implications of these GWAS findings in relation to biological mechanism, potential drug target identification and genetic risk stratification of disease. Amongst the medication-associated genes are 16 known therapeutic-effect target genes for medications from 9 cat

  • Common genetic variation indicates separate etiologies for periventricular and deep white matter hyperintensities - Unknown journal (n.d.) · Unknown authors · PubMed 32517579

    ABSTRACT: Background and Purpose Periventricular (PVWMH) and deep white matter hyperintensities (DWMH) are regional classifications of white matter hyperintensities (WMH) and reflect proposed differences in etiology. In the first study to date, we undertook genome-wide association analyses (GWAS) of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. Methods Participants were aged 45 years and older; free of stroke and dementia. We conducted GWAS of PVWMH and DWMH in 26,654 participants from CHARGE, ENIGMA, and the UK Biobank (UKB). Regional correlations were investigated using the GWAS-pairwise method. Cross-trait genetic correlations between PVWMH, DWMH, stroke, and dementia were estimated using LDSC. Results In the discovery and replication analysis, for P

  • GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer - Unknown journal (n.d.) · Unknown authors · PubMed 34021172

    ABSTRACT: Genetic studies have examined body-shape measures adjusted for body mass index (BMI), while allometric indices are additionally adjusted for height. We performed the first genome-wide association study of A Body Shape Index (ABSI), Hip Index (HI) and the new Waist-to-Hip Index and compared these with traditional indices, using data from the UK Biobank Resource for 219,872 women and 186,825 men with white British ancestry and Bayesian linear mixed-models (BOLT-LMM). One to two thirds of the loci identified for allometric body-shape indices were novel. Most prominent was rs72959041 variant in RSPO3 gene, expressed in visceral adipose tissue and regulating adrenal cell renewal. Highly ranked were genes related to morphogenesis and organogenesis, previously additionally linked to can

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