Expressive

rs10931281 - CALCRL-AS1

Magnitude 2.2 · 1 study on file

Reported associations

  • Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank. - Hernia : the journal of hernias and abdominal wall surgery (2022) · Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J · PubMed 34382107

    Familial aggregation is known for both hernia development and recurrence. To date, only one genome-wide association study (GWAS) limited to inguinal hernia has been reported that identified four risk-associated loci. We aim to investigate polygenic architecture of abdominal wall hernia development and recurrence. A GWAS was performed in 367,394 subjects from the UK Biobank to investigate the polygenic architecture of abdominal wall hernia subtypes (inguinal, femoral, umbilical, ventral) and identify specific single nucleotide polymorphisms (SNPs) that are associated with their risk. Expression quantitative trait loci (eQTL) analysis was performed to identify genes whose expression levels are associated with these SNPs. A genetic risk score (GRS) was used to assess the cumulative effect of

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Lifestyle

  • body weight and abdominal pressure Moderate

    Obesity increases intra-abdominal pressure and hernia risk; genetic predisposition amplifies this risk.

    Maintain BMI 18.5-24.9 through regular physical activity and balanced nutrition.

  • repetitive heavy lifting and straining Moderate

    Heavy lifting increases intra-abdominal pressure; this variant is associated with elevated hernia risk.

    Limit heavy lifting; use proper body mechanics; ask for assistance with loads over 25 pounds.

Screening

  • hernia risk and clinical screening Moderate

    This genetic variant is associated with increased inguinal hernia risk; clinical assessment enables early detection.

    Discuss hernia risk with physician; monitor for groin bulging, pain with lifting or straining.