Expressive

rs1092913 - ROPN1L

Magnitude 4.5 · 2 studies on file

Reported associations

  • Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility - Unknown journal (n.d.) · Unknown authors · PubMed 21424380

    ABSTRACT: Previous genome-wide association studies (GWAS) have shown several risk alleles to be associated with breast cancer. However, the variants identified so far contribute to only a small proportion of disease risk. The objective of our GWAS was to identify additional novel breast cancer susceptibility variants and to replicate these findings in an independent cohort. We performed a two-stage association study in a cohort of 3,064 women from Alberta, Canada. In Stage I, we interrogated 906,600 single nucleotide polymorphisms (SNPs) on Affymetrix SNP 6.0 arrays using 348 breast cancer cases and 348 controls. We used single-locus association tests to determine statistical significance for the observed differences in allele frequencies between cases and controls. In Stage II, we attempt

  • Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females - Unknown journal (n.d.) · Unknown authors · PubMed 31170924

    ABSTRACT: Background Metabolic syndrome (MetS), defined as a cluster of metabolic risk factors including dyslipidemia, insulin-resistance, and elevated blood pressure, has been known as partly heritable. MetS effects the lives of many people worldwide, yet females have been reported to be more vulnerable to this cluster of risks. Methods To elucidate genetic variants underlying MetS specifically in females, we performed a genome-wide association study (GWAS) for MetS as well as its component traits in a total of 9932 Korean female subjects (including 2276 MetS cases and 1692 controls). To facilitate the prediction of MetS in females, we calculated a genetic risk score (GRS) combining 14 SNPs detected in our GWA analyses specific for MetS. Results GWA analyses identified 14 moderate signals

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Lifestyle context

Concrete actions anchored to the cited research. We do not prescribe, we describe.

Diet

  • reduced refined carbohydrates and added sugars Moderate

    Refined carbohydrates drive triglyceride synthesis; limiting them is particularly important for genetic predisposition carriers

    Emphasize whole grains, vegetables, lean proteins, and healthy fats; minimize sugary beverages and processed foods

Discuss with your doctor

  • genetic predisposition to elevated triglycerides Moderate

    rs1092913 G allele carriers have baseline triglyceride elevation; physician guidance optimizes management

    Discuss with your doctor; consider medication if lifestyle changes do not adequately reduce triglycerides

Screening

  • fasting triglyceride levels Moderate

    rs1092913 G allele increases baseline triglycerides by approximately 7.5 mg/dL per copy in women

    Obtain baseline fasting lipid panel if not done recently; repeat every 1-2 years or if diet/exercise changes significantly