rs10927108 - LINC02774

Magnitude 2.8 · 1 study on file

Reported associations

• Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation - Unknown journal (n.d.) · Unknown authors · PubMed 34746714

  ABSTRACT: Background Identification of non-human leukocyte antigen (HLA) genetic risk factors could improve survival after allogeneic blood or marrow transplant (BMT) through matching at additional loci or individualizing risk prediction. We hypothesized that non-HLA loci contributed significantly to 1-year overall survival (OS), disease related mortality (DRM) or transplant related mortality (TRM) after unrelated donor (URD)BMT. Methods We performed a genome-wide association study (GWAS) in 2,887 acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and acute lymphoblastic leukemia (ALL) patients and their ≥8/8 HLA-matched URDs comprising two independent cohorts treated from 2000-2011. Findings Using meta-analyses of both cohorts, genome-wide significant associations (p < 5 

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