rs10924970 - ARID4B
Magnitude 2.8 · 1 study on file
Reported associations
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Multiancestry association study identifies new asthma risk loci that colocalize with immune cell enhancer marks - Unknown journal (n.d.) · Unknown authors · PubMed 29273806
ABSTRACT: We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 cases, 118,538 controls) from ethnically-diverse populations. We identified five new asthma loci, uncovered two additional novel associations at two known asthma loci, established asthma associations at two loci implicated previously in comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. Enrichment of asthma risk loci in enhancer marks, especially in immune cells, suggests a major role of these loci in the regulation of immune-related mechanisms. FULL TEXT: [INTRO] Asthma is a complex disease affecting hundreds of milli
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Lifestyle
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Minimize respiratory irritants in living environment Moderate
Genetic asthma predisposition increases susceptibility to environmental triggers that may precipitate disease onset
Use HEPA air filters, reduce smoke exposure, manage mold in living spaces
Screening
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Early pulmonary function screening Moderate
Genetic variant associated with 25 percent increased asthma risk, warranting early respiratory assessment
Baseline spirometry or peak expiratory flow testing