rs10923243 - VTCN1 - Metazoa_SRP

Magnitude 4.5 · 1 study on file

Reported associations

• Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease. - American heart journal plus : cardiology research and practice (2022) · Dungan JR, Qin X, Gregory SG, Cooper-Dehoff R, Duarte JD, Qin H, Gulati M, Taylor JY, Pepine CJ, Hauser ER, Kraus WE · PubMed 35959094

  Ischemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is presumed to be a major factor underlying sex differences for IHD events, including mortality. The purpose of this study was to identify sex-specific candidate genes associated with all-cause mortality among people diagnosed with coronary artery disease (CAD). We performed a sex-stratified, exploratory genome-wide association (GWAS) screen using existing data from CAD-diagnosed males ( = 510) and females ( = 174) who reported European ancestry from the Duke Catheterization Genetics biorepository. Extant genotype data for 785,945 autosomal SNPs generated with the Human Omni1-Quad BeadChip (Illumina, CA, USA) were analyzed using an additive inheritance model. We estimated instantaneous risk of

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