rs10922142 - CFHR1 - CFHR4
Magnitude 2.2 · 1 study on file
Reported associations
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Dyslipidaemia-Genotype Interactions with Nutrient Intake and Cerebro-Cardiovascular Disease - Unknown journal (n.d.) · Unknown authors · PubMed 35884923
ABSTRACT: A comprehensive understanding of gene-diet interactions is necessary to establish proper dietary guidelines to prevent and manage cardio-cerebrovascular disease (CCD). We investigated the role of genetic variants associated with dyslipidaemia (DL) and their interactions with macro-nutrients for cardiovascular disease using a large-scale genome-wide association study of Korean adults. A total of 58,701 participants from a Korean genome and epidemiology study were included. Their dietary intake was assessed using a food frequency questionnaire. Dyslipidaemia was defined as total cholesterol (TCHL) ≥ 240 mg/dL, high-density lipoprotein (HDL) < 40 mg/dL, low-density lipoprotein (LDL) ≥ 160 mg/dL, triglycerides (TG) ≥ 200 mg/dL, or dyslipidaemia history. Their nutrient intake wa
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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Cardiovascular risk stratification Moderate
CFHR1/3 genes regulate complement system and cholesterol metabolism; this variant increases cholesterol-related cardiovascular disease risk.
Discuss with healthcare provider for personalized risk assessment.
Screening
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Lipid panel Moderate
rs10922142 risk allele is associated with elevated total cholesterol via effects on CFHR1/3 expression in liver and adipose tissue, key sites of lipid metabolism.
Annual lipid panel starting at age 25-30, or per standard guidelines.