rs10920654 - BRINP3

Magnitude 4.5 · 1 study on file

Reported associations

• A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer. - BMC cancer (2020) · Penney ME, Parfrey PS, Savas S, Yilmaz YE · PubMed 30738427

  Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability (MSI)-high tumor phenotype is such a differentiator in colorectal cancer, as patients with these tumors are unlikely to experience metastasis. Our aim in this study was to determine if germline genetic variations could further differentiate colorectal cancer patients based on the long-term risk and timing of metastasis. The patient cohort consisted of 379 stage I-III Caucasian colorectal cancer patients with microsatellite stable or MSI-low tumors. We performed univariable analysis on 810,622 common single nucleotide polymorphisms (SNPs) under different genetic models. Depending on t

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