rs10920424 - LINC01701 - BRINP3

Magnitude 2.2 · 1 study on file

Reported associations

• Shared genetic architectures of subjective well-being in East Asian and European ancestry populations. - Nature human behaviour (2022) · Kim S, Kim K, Hwang MY, Ko H, Jung SH, Shim I, Cha S, Lee H, Kim B, Yoon J, Ha TH, Kim DK, Kim J, Park WY, Okbay A, Kim BJ, Kim YJ, Myung W, Won HH · PubMed 35589828

  Subjective well-being (SWB) has been explored in European ancestral populations; however, whether the SWB genetic architecture is shared across populations remains unclear. We conducted a cross-population genome-wide association study for SWB using samples from Korean (n = 110,919) and European (n = 563,176) ancestries. Five ancestry-specific loci and twelve cross-ancestry significant genomic loci were identified. One novel locus (rs12298541 near HMGA2) associated with SWB was also identified through the European meta-analysis. Significant cross-ancestry genetic correlation for SWB between samples was observed. Polygenic risk analysis in an independent Korean cohort (n = 22,455) demonstrated transferability between populations. Significant correlations between SWB and major dep

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