rs10919062 - ATP1B1

Magnitude 4.5 · 1 study on file

Reported associations

• Monogenic and Polygenic Contributions to QTc Prolongation in the Population - Unknown journal (n.d.) · Unknown authors · PubMed 35389749

  ABSTRACT: Background: Rare sequence variation in genes underlying cardiac repolarization and common polygenic variation influence QT interval duration. However, current clinical genetic testing of individuals with unexplained QT prolongation is restricted to examination of monogenic rare variants. The recent emergence of large-scale biorepositories with sequence data enables examination of the joint contribution of rare and common variation to the QT interval in the population. Methods: We performed a genome wide association study (GWAS) of the QTc in 84,630 United Kingdom Biobank (UKB) participants and created a polygenic risk score (PRS). Among 26,976 participants with whole genome sequencing and electrocardiogram data in the Trans-Omics for Precision Medicine (TOPMed) program, we identi

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