rs10917760 - NUF2 - RNA5SP62

Magnitude 4.5 · 1 study on file

Reported associations

• Genetic risk score combining six genetic variants associated with the cellular NRF2 expression levels correlates with Type 2 diabetes in the human population. - Genes & genomics (2019) · Shin JH, Lee KM, Shin J, Kang KD, Nho CW, Cho YS · PubMed 30767168

  Type 2 diabetes (T2D) is known as an inflammatory disease. NRF2 (Nuclear Factor Erythroid 2 Like2) encodes a transcription factor that binds to antioxidant response elements (AREs) and regulates the expression of genes involved in many antioxidant responses. This study aimed to gain insight into individual anti-inflammatory activity to prevent T2D development in humans. We performed a genome-wide association study (GWAS) to identify genetic variants influencing NRF2 expression in LCLs (lymphoblastoid cell lines) generated from 74 different individuals. Association analyses between T2D or its related traits and genetic risk score (GRS) calculated by combining genetic variants detected from GWAS for cellular NRF2 expression were performed using data from 8715 subjects. The T2D prediction mod

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