rs10916661 - RNF186-AS1 - OTUD3

Magnitude 4.5 · 1 study on file

Reported associations

• Genome-wide association study of warfarin maintenance dose in a Brazilian sample - Unknown journal (n.d.) · Unknown authors · PubMed 26265036

  ABSTRACT: Aim Extreme discordant phenotype and genome-wide association (GWA) approaches were combined to explore the role of genetic variants on warfarin dose requirement in Brazilians. Methods Patients receiving low (≤20 mg/week; n = 180) or high stable warfarin doses (≥42.5 mg/week; n = 187) were genotyped with Affymetrix Axiom® Biobank arrays. Imputation was carried out using data from the combined 1000 Genomes project. Results Genome-wide signals (p ≤5 × 10−8) were identified in the well-known VKORC1 (lead SNP, rs749671; OR: 20.4; p = 1.08 × 10−33) and CYP2C9 (lead SNP, rs9332238, OR: 6.8 and p = 4.4 × 10−13) regions. The rs9332238 polymorphism is in virtually perfect LD with CYP2C92 (rs1799853) and CYP2C93 (rs1057910). No other genome-wide significant regions were id

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