rs10916409 - RHOU - LINC02814

Magnitude 2.0 · 1 study on file

Reported associations

• Genome-wide association study of white matter hyperintensity volume in elderly persons without dementia - NeuroImage. Clinical (2021) · Guo Y, Shen XN, Hou XH, Ou YN, Huang YY, Dong Q, Tan L, Yu JT · PubMed 32062564

  ABSTRACT: Highlights We conducted a GWAS to identify genetic loci linked to WMHV in non-demented elders. Rs7220676 near HS3ST3A1 and MIR548H3 genes was significantly associated with WMHV. Rs7220676 was also correlated with rates of cognitive decline. Background White matter hyperintensity has been correlated with cognitive disorders and its genetic predictors remain unclear. Here we conducted a genome-wide association study to identify novel genetic determinants that were correlated with white matter hyperintensity volume (WMHV) among non-demented elders. Methods Three hundred and fifty non-Hispanic Caucasian subjects aged 55-80 years were included from the Alzheimer's Disease Neuroimaging Initiative cohort. Associations of WMHV with genetic polymorphisms were explored using multiple lin

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