rs10912903 - KIAA0040
Magnitude 2.2 · 1 study on file
Reported associations
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New and sex-specific migraine susceptibility loci identified from a multiethnic genome-wide meta-analysis - Unknown journal (n.d.) · Unknown authors · PubMed 34294844
ABSTRACT: Migraine is a common disabling primary headache disorder that is ranked as the most common neurological cause of disability worldwide. Women present with migraine much more frequently than men, but the reasons for this difference are unknown. Migraine heritability is estimated to up to 57%, yet much of the genetic risk remains unaccounted for, especially in non-European ancestry populations. To elucidate the etiology of this common disorder, we conduct a multiethnic genome-wide association meta-analysis of migraine, combining results from the GERA and UK Biobank cohorts, followed by a European-ancestry meta-analysis using public summary statistics. We report 79 loci associated with migraine, of which 45 were novel. Sex-stratified analyses identify three additional novel loci (CPS
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Lifestyle context
Concrete actions anchored to the cited research. We do not prescribe, we describe.
Discuss with your doctor
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preventive migraine treatments and management strategies Moderate
Elevated genetic susceptibility to migraine identified by this SNP makes early preventive intervention more valuable, as evidence-based prevention options significantly reduce migraine burden.
Discuss available preventive approaches (medications and behavioral strategies) with healthcare provider
Screening
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screen for migraine symptoms regularly Moderate
Carriers of the G risk allele have significantly elevated migraine susceptibility based on large-scale GWAS (n=889018, p=7e-9), with approximately 3% increased odds per risk allele.
Assess for migraine symptoms at routine medical visits; consider migraine diary if symptoms emerge